Graduating from Bosse High School and the University of Evansville, Marty Amsler played for many teams in the NFL, such as the Chicago Bears, Cincinnati Bengals, and Green Bay Packers.

Conrad Baker, the 15th Lieutenant Governor and the 15th Governor of Indiana, settled down in Evansville with his family in 1841.

Former player and coach of the Indiana Hoosiers men's basketball team, Phelps Darby, was born in Evansville.

Born in Evansville, Bob Ford attended North High School, played basketball at Purdue University, and played professionally for the Memphis Tams and Lafayette Lasers.

Former President of the Indiana Federation of Colored Women, Sallie Wyatt Stewart, spent a part of her life going to school and eventually teaching in Evansville.

Oklahoma's seventh Governor, Henry S. Johnston, was a native to Evansville.

Edwin Denby, appointed Secretary of the Navy in 1921, was born in Evansville. He was also a notable figure in the Teapot Dome scandal.

Former MLB pitcher, Alan Benes, was born in Evansville. He played for the St. Louis Cardinals, Chicago Cubs, and Texas Rangers.

Competition swimmer and twelve-time medalist, Michael Klueh, was born in Evansville. He competed at the World Championships and the World University Games.

The 45th Governor of Indiana, Robert D. Orr, grew up in Evansville. His family has lived in the area for three generations.