American diplomat in China and later in Austria, Charles Denby Jr. was born in Evansville. He was known as a top scholar of Chinese language and culture.

Charles Harvey Denby, a U.S. Union officer in the Civil War and diplomat,, lived most of his life in Evansville. When he moved to Evansville in 1853, there were six thousand residents.

Evansville native and graduate of the University of Evansville, James Meyer was an assistant spacecraft manager for Apollo 11. He helped with planning and scheduling Apollo 11's command module.

Evansville Lutheran School and Central High School attendee, Andy Benes was an MLB pitcher for the St. Louis Cardinals, Arizona Diamondbacks, and more. In 1988, he was the #1 MLB draft pick and a part of the US Olympic team.

Physician and U.S. minister of Liberia, George Washington Buckner settled down in Evansville where he opened a doctor's office.

Graduating from Bosse High School and the University of Evansville, Marty Amsler played for many teams in the NFL, such as the Chicago Bears, Cincinnati Bengals, and Green Bay Packers.

Conrad Baker, the 15th Lieutenant Governor and the 15th Governor of Indiana, settled down in Evansville with his family in 1841.

Former player and coach of the Indiana Hoosiers men's basketball team, Phelps Darby, was born in Evansville.

Born in Evansville, Bob Ford attended North High School, played basketball at Purdue University, and played professionally for the Memphis Tams and Lafayette Lasers.

Former President of the Indiana Federation of Colored Women, Sallie Wyatt Stewart, spent a part of her life going to school and eventually teaching in Evansville.